منابع مشابه
Ionic Blockage of Sodium Channels in Nerve
Increasing the hydrogen ion concentration of the bathing medium reversibly depresses the sodium permeability of voltage-clamped frog nerves. The depression depends on membrane voltage: changing from pH 7 to pH 5 causes a 60% reduction in sodium permeability at +20 mV, but only a 20% reduction at +180 mV. This voltage-dependent block of sodium channels by hydrogen ions is explained by assuming t...
متن کاملIonic blockage of the light-regulated sodium channels in isolated rod outer segments
We have investigated, with osmotic techniques, the light-regulated Na+ channels in rod outer segments (ROS) and ROS fragments freshly isolated from the frog retina. Values of Na+ permeability (PNa) similar to those observed electrophysiologically in the retina were observed using the osmotic technique (continuous flow) described by Korenbrot and Cone. In the other osmotic techniques that we exp...
متن کاملIonic Channels and Nerve Membrane Constituents
Saxitoxin (STX) and tetrodotoxin (TTX) have the same striking property of blocking the Na(+) channels in the axolemma. Experiments with nerve plasma membrane components of the squid Dosidicus gigas have shown that TTX interacts with cholesterol monolayers. Similar experiments were carried out with STX. The effect of STX on the surface pressure-area diagrams of lipid monolayers and on the fluore...
متن کاملIonic Channels and Nerve Membrane Lipids
Experiments were carried out to investigate possible interactions of tetrodotoxin (TTX) with lipid molecules isolated from nerve fiber plasma membranes of the squid Dosidicus gigas. TTX has a highly selective ability to block the channel normally used by Na+ to cross the axolemma during nervous impulse conduction. In order to investigate the interaction each lipid sample was spread on 5 X 10 -7...
متن کاملintercostal nerve blockage in cholecystectomy
four patients were studied for intercostals nerve blockade in cholecystectomy. all of the patients were poor risks (class 4) and received premedication before the procedure. intercostals nerve blockade (icnb) of the 7th and 10th thoracic nerves on the right side was performed with lidocaine 1% plus adrenaline 5 ml. at each segment, t7-t10 (a total dose of 20 ml). ventilation was controlled usin...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1973
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.61.6.687